Drug forms of levothyroxine. Is there room for innovation in hypothyroidism treatment?

Levothyroxine steadily maintains its position as the «gold standard» in treatment of hypothyroidism. Despite possibility step-by-step tableted dose titration levothyroxine, results many studies reliably point to fact that a significant number patients do not reach target level thyroid hormone. One main reasons for therapy ineffectiveness is inconvenience levothyroxine sodium regimen patients, associated with need observe certain time intervals before meals and other medications. The above-mentioned factors have stimulated aimed at developing new dosage forms advantages pharmacokinetics pharmacodynamics drugs. review provides latest data on levothyroxine. Further large-scale clinical trials are needed more reasonable widespread use practice.